Lysophosphatidic Acid Increases Maturation of Brush Borders and SGLT1 Activity in MYO5B-deficient Mice, a Model of Microvillus Inclusion Disease

Mutations in the gene MYO5B cause the congenital diarrheal disease, microvillus inclusion disease (MVID). Using a mouse model of MVID, Jim Goldenring and colleagues found that administration of Lysophosphatidic Acid (LPA) which is found in many common foods is able to reverse some of the epithelial changes seen in MVID mice.

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Kaji et al Gastro 2020