Mutations in the gene MYO5B cause the congenital diarrheal disease, microvillus inclusion disease (MVID). Using a mouse model of MVID, Jim Goldenring and colleagues found that administration of Lysophosphatidic Acid (LPA) which is found in many common foods is able to reverse some of the epithelial changes seen in MVID mice.
Read more about this study:
Kaji et al Gastro 2020
Vanderbilt University Medical Center
Boston Children’s Hospital
University of California, Los Angeles (UCLA)
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